Typhoid Fever

Typhoid fever is caused by Salmonella typhi, the typhoid bacillus. At present, there are 107 different strains of the bacteria. Typhoid fever is still common in the developing world, where it affects about 17 million persons each year with approximately 600,000 deaths. Salmonella Typhi lives only in humans. People with typhoid fever carry the bacteria in their bloodstream and intestinal tract. In addition, a small number of persons called carriers, recover from typhoid fever but continue to carry the bacteria. Both ill persons and carriers shed S. Typhi in their faeces (stool). Severe forms have been described with mental dullness and meningitis. Case-fatality rates of 10% can be reduced to less than 1% with appropriate antibiotic therapy.

Transmission: Typhoid fever is transmitted by food and water contaminated by the faeces and urine of patients and carriers. Polluted water is the most common source of typhoid. In addition, shellfish taken from sewage contaminated beds, vegetables fertilized by nightsoil and eaten raw, contaminated milk and milk products have been shown as a source of infection.

Manifestations: Persons with typhoid fever usually have a sustained:

Diagnosis and treatment: The only way to know for sure if an illness is typhoid fever is to have samples of stool or blood tested for the presence of S. Typhi. Treatment with antibiotics is available.

Vaccination: Immunisation for typhoid fever is recommended for international travellers to endemic areas, especially if travel will involve exposure to unsafe food and water or close contact in rural areas and with indigenous populations.

Prevent typhoid fever by:

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